Vulnerabilities in pkg:pypi/openbabel

PACKAGE
Advisory Identifier: GHSA-55f6-pf8r-c2f4
Advisory Summary

CVE-2022-46292 is a HIGH (CVSS 7.8) open babel has out-of-bounds write vulnerability (CWE-787: Out-of-bounds Write) affecting Openbabel libraries in the PyPI ecosystem. The issue involves open babel has out-of-bounds write in mopac translationvectors[] (unit cell translation). Remediation is available by upgrading affected packages to version 3.2.0.

48 Known Advisory Record(s)
Package Vulnerability Intelligence

pkg:pypi/openbabel

48 Known Advisory Record(s)

Vulnerability advisories affecting package pkg:pypi/openbabel. Select an advisory below to view technical details or fixes.

Advisory ID CVE / NVD Severity Summary
GHSA-55f6-pf8r-c2f4 CVE-2022-46292 HIGH Open Babel has out-of-bounds write in MOPAC translationVectors[] (UNIT CELL TRANSLATION)
GHSA-hrvg-gx3j-wh53 - CRITICAL Duplicate Advisory: Open Babel has out-of-bounds write in MOPAC translationVectors[] (UNIT CELL TRANSLATION)
GHSA-f8h2-c479-vqxf CVE-2022-46295 HIGH Open Babel has out-of-bounds write in MSI translationVectors[]
GHSA-83c5-hghm-jg6r - CRITICAL Duplicate Advisory: Open Babel has out-of-bounds write in MSI translationVectors[]
GHSA-mjmg-352j-f456 CVE-2022-46294 HIGH Open Babel has out-of-bounds write in MOPAC IN translationVectors[] (Tv atom)
GHSA-jrjj-9h77-6vhv - CRITICAL Duplicate Advisory: Open Babel has out-of-bounds write in MOPAC IN translationVectors[] (Tv atom)
GHSA-7h6r-6p76-68c9 CVE-2022-46293 HIGH Open Babel has out-of-bounds write in MOPAC translationVectors[] (FINAL POINT)
GHSA-4r3q-94wc-xhq9 - CRITICAL Duplicate Advisory: Open Babel has out-of-bounds write in MOPAC translationVectors[] (FINAL POINT)
GHSA-jg3h-pv7c-4f9c CVE-2022-46291 HIGH Open Babel has out-of-bounds write in Gaussian translationVectors[]
GHSA-v5fw-q4pf-8p2h - CRITICAL Duplicate Advisory: Open Babel has out-of-bounds write in Gaussian translationVectors[]
GHSA-5rff-8f7c-8jmw CVE-2022-46290 HIGH Open Babel has out-of-bounds write in ORCA nAtoms parser (second variant)
GHSA-wj42-v2p3-fq2w - CRITICAL Duplicate Advisory: Open Babel has out-of-bounds write in ORCA nAtoms parser (second variant)
GHSA-rj4c-r689-cm87 CVE-2022-46289 HIGH Open Babel has out-of-bounds write in ORCA nAtoms parser
GHSA-g8f4-g673-rfw2 - CRITICAL Duplicate Advisory: Open Babel has out-of-bounds write in ORCA nAtoms parser
GHSA-8qxc-57hf-hc9j CVE-2022-46280 HIGH Open Babel has uninitialized pointer dereference in PQS pFormat
GHSA-7rcm-w6ff-j43w - CRITICAL Duplicate Advisory: Open Babel has uninitialized pointer dereference in PQS pFormat
GHSA-jr2x-6qf6-q5mc CVE-2022-44451 HIGH Open Babel has uninitialized pointer dereference in MSI atom parser
GHSA-x3cp-4x6w-vm7p - CRITICAL Duplicate Advisory: Open Babel has out-of-bounds write in MOL2 attribute/value parser
GHSA-vjg6-gm8m-v5g6 CVE-2022-43607 HIGH Open Babel has out-of-bounds write in MOL2 attribute/value parser
GHSA-qghv-8h77-699v - HIGH Duplicate Advisory: Open Babel has out-of-bounds write in MOL2 attribute/value parser
GHSA-f29h-2h58-48r7 CVE-2022-43467 HIGH Open Babel has out-of-bounds write in PQS coord_file parser
GHSA-vx29-rwgr-834p - CRITICAL Duplicate Advisory: Open Babel has out-of-bounds write in PQS coord_file parser
GHSA-mw5r-wq2m-397c CVE-2022-42885 HIGH Open Babel has uninitialized pointer dereference in GRO residue parser
GHSA-h632-qvv7-2623 - CRITICAL Duplicate Advisory: Open Babel has uninitialized pointer dereference in GRO residue parser
GHSA-p594-7xw4-g76p CVE-2022-41793 HIGH Open Babel has out-of-bounds write in CSR PadString (title field)
GHSA-jmf7-79p7-qchq - CRITICAL Duplicate Advisory: Open Babel has out-of-bounds write in CSR PadString (title field)
GHSA-vr3p-gg26-45v9 CVE-2022-37331 HIGH Open Babel has out-of-bounds write in Gaussian coords_type orientation parser
GHSA-8rrv-fjvg-6vcx - HIGH Duplicate Advisory: Open Babel has out-of-bounds write in Gaussian coords_type orientation parser
GHSA-m982-7q3h-r784 CVE-2025-11000 MODERATE Open Babel has out-of-bounds read in PQS lowerit (pre-buffer read)
GHSA-7x26-54jj-cvhr - LOW Duplicate Advisory: Open Babel has out-of-bounds read in PQS lowerit (pre-buffer read)
GHSA-55j6-rjhx-hwfh CVE-2025-10999 MODERATE Open Babel has NULL pointer dereference in CACAO CacaoFormat::SetHilderbrandt
GHSA-62mq-grc2-53j3 - LOW Duplicate Advisory: Open Babel has NULL pointer dereference in CACAO CacaoFormat::SetHilderbrandt
GHSA-j9pp-7wfg-q7fj CVE-2025-10998 LOW Open Babel has NULL pointer dereference in ChemKinFormat::ReadReactionQualifierLines
GHSA-hvp2-4h2f-26w4 - LOW Duplicate Advisory: Open Babel has NULL pointer dereference in ChemKinFormat::ReadReactionQualifierLines
GHSA-8wq6-qh76-wpv9 CVE-2025-10997 HIGH Open Babel has heap buffer overflow in ChemKin ChemKinFormat::CheckSpecies
GHSA-95gx-jmhp-5p29 - LOW Duplicate Advisory: Open Babel has heap buffer overflow in ChemKin ChemKinFormat::CheckSpecies
GHSA-j35x-w4gj-pf7w CVE-2025-10996 HIGH Open Babel has heap buffer overflow in SMILES OBSmilesParser::ParseSmiles
GHSA-9p6c-jcw8-x98f - LOW Duplicate Advisory: Open Babel has heap buffer overflow in SMILES OBSmilesParser::ParseSmiles
GHSA-8j3x-m868-cpw8 CVE-2025-10995 LOW Open Babel has out-of-bounds write (overlapping memcpy) in zipstream basic_unzip_streambuf::underflow
GHSA-5gfq-xrq4-34rj - LOW Duplicate Advisory: Open Babel has out-of-bounds write (overlapping memcpy) in zipstream basic_unzip_streambuf::underflow
GHSA-pp85-5j63-xpq3 CVE-2025-10994 LOW Open Babel has Use-after-free in GAMESS GAMESSOutputFormat::ReadMolecule
GHSA-5fgf-q57f-wwqf - LOW Duplicate Advisory: Open Babel has Use-after-free in GAMESS GAMESSOutputFormat::ReadMolecule
GHSA-rxpr-wq63-jr7p CVE-2026-3408 LOW Open Babel has a NULL pointer dereference in CDXML OBAtom::GetExplicitValence
GHSA-fg6r-xgp8-x64r - LOW Duplicate Advisory: Open Babel has a NULL pointer dereference in CDXML OBAtom::GetExplicitValence
GHSA-4w5w-4fhm-q483 CVE-2026-2705 LOW Open Babel has NULL pointer dereference in MOL2 OBAtom::SetFormalCharge
GHSA-3f56-w4g2-mx64 - LOW Duplicate Advisory: Open Babel has NULL pointer dereference in MOL2 OBAtom::SetFormalCharge
GHSA-6xw4-2g22-26h8 CVE-2026-2704 LOW Open Babel has an out-of-bounds read in CIF transform3d::DescribeAsString
GHSA-2m54-8m6g-qf93 - LOW Duplicate Advisory: Open Babel has an out-of-bounds read in CIF transform3d::DescribeAsString

CVE-2022-46292 at a Glance

CVE Identifier CVE-2022-46292
GHSA Identifier GHSA-55f6-pf8r-c2f4
Severity HIGH
CVSS v3.1 Base Score 7.8
CWE Classification CWE-787: Out-of-bounds Write
Affected Product Openbabel
Package Ecosystem PyPI
Published Date
Last Updated

Security Impact

CVSS: 7.8

The security impact metrics below are parsed directly from the CVSS v3.1 vector string (CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H).

Attack Vector Local (AV:L)
Attack Complexity Low (AC:L)
Privileges Required None (PR:N)
User Interaction Required (UI:R)
Scope Unchanged (S:U)
Confidentiality High (C:H)
Integrity High (I:H)
Availability High (A:H)

How to Fix CVE-2022-46292

To remediate this vulnerability, upgrade all affected Openbabel dependencies to a patched release. Both direct and transitive dependencies should be checked, as frameworks or security libraries may pull in vulnerable versions transitively.

openbabel fixed: 3.2.0
pip install openbabel>=3.2.0
Verify Direct and Transitive Dependencies

Run the following command in your project directory to verify that all resolved dependencies use the patched release:

pip show openbabel

How to Check if You Are Affected

To determine whether your Python environment is affected by CVE-2022-46292, inspect your installed packages using pip:

pip show openbabel

Analyze the terminal output to locate any version of Openbabel in your dependency tree. If any resolved version matches the vulnerable ranges listed in the table below (for example, versions earlier than 3.2.0), your application is affected.

Note: The pip show openbabel command checks currently installed packages in your active Python environment.

Technical Details

Vulnerability Mechanism & Technical Analysis

This vulnerability is classified under CWE-787: Out-of-bounds Write, where the product writes data past the end, or before the beginning, of the intended buffer. In Openbabel, software state validation or input boundaries are circumvented during processing. Review the official source advisory statement below for specific affected components, classes, and reproduction details.

Source Advisory Statement

### Summary A memory-safety vulnerability in Open Babel's MOPAC output parser allowed an out-of-bounds write into the `translationVectors[]` array when reading the "UNIT CELL TRANSLATION" block of a crafted input file. ### Details The MOPAC output reader stored translation vectors from the UNIT CELL TRANSLATION block into a fixed-size `translationVectors[]` array. A malformed block could push more vectors than the array had slots, causing a write past the end of the array. One of five `translationVectors[]` OOB writes in the TALOS 2022 batch. ### Impact Open Babel is a C++ library and CLI used to read and write chemistry file formats; it is shipped by Linux distributions and embedded in services that may parse untrusted input. Triggering this vulnerability requires the victim to open a malicious MOPAC output file with the `obabel` tool, the `OBConversion` API, or any of the language bindings (Python, Ruby, Java, R, Perl, C#, PHP). ### Affected versions All releases up to and including 3.1.1. ### Patched version 3.2.0 (released 2026-05-26). ### Patch Fix commit: https://github.com/openbabel/openbabel/commit/40e85213 A minimized reproducer for this CVE is checked in under `test/files/fuzz_regress/` and is exercised on every CI build under ASAN+UBSAN by the `fuzzregresstest` harness. ### Credit Reported by Cisco TALOS.

CVE-2022-46292 Affected Openbabel Versions

1 component(s)
Fixed Versions:
3.2.0
Product / Package Ecosystem Affected Versions Fixed Version
openbabel
PyPI
< 3.2.0
3.2.0

References

Frequently Asked Questions

What is CVE-2022-46292?
CVE-2022-46292 is a security vulnerability in Openbabel involving Open Babel has out-of-bounds write in MOPAC translationVectors[] (UNIT CELL TRANSLATION) under CWE-787: Out-of-bounds Write.
Which Openbabel versions are affected?
Affected versions include releases prior to 3.2.0 across affected packages: openbabel.
What version fixes CVE-2022-46292?
Upgrading to 3.2.0 (or the latest patched release for your respective branch) resolves the vulnerability.
Is openbabel affected?
Yes, openbabel is affected in releases prior to 3.2.0. Upgrade your dependency to 3.2.0 or later.
What is the CVSS score of CVE-2022-46292?
CVE-2022-46292 has a CVSS v3.1 base score of 7.8 (HIGH) with vector string CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H.
What CWE is associated with CVE-2022-46292?
CVE-2022-46292 is classified under CWE-787: Out-of-bounds Write (The product writes data past the end, or before the beginning, of the intended buffer.).
How can I check PyPI dependencies for CVE-2022-46292?
Run the dependency tree command: 'pip show openbabel'. This command lists direct and transitive dependencies in your build configuration so you can verify if a vulnerable version is resolved.
Machine-readable OSV JSON OSV v1.5 Schema
Normalized schema output
{
  "schema_version" : "1.4.0",
  "id" : "GHSA-55f6-pf8r-c2f4",
  "modified" : "2026-07-06T16:41:43Z",
  "published" : "2026-07-06T16:41:43Z",
  "aliases" : [ "CVE-2022-46292" ],
  "summary" : "Open Babel has out-of-bounds write in MOPAC translationVectors[] (UNIT CELL TRANSLATION)",
  "details" : "### Summary\n\nA memory-safety vulnerability in Open Babel's MOPAC output parser\nallowed an out-of-bounds write into the `translationVectors[]` array\nwhen reading the \"UNIT CELL TRANSLATION\" block of a crafted input\nfile.\n\n### Details\n\nThe MOPAC output reader stored translation vectors from the UNIT CELL\nTRANSLATION block into a fixed-size `translationVectors[]` array. A\nmalformed block could push more vectors than the array had slots,\ncausing a write past the end of the array. One of five\n`translationVectors[]` OOB writes in the TALOS 2022 batch.\n\n### Impact\n\nOpen Babel is a C++ library and CLI used to read and write chemistry\nfile formats; it is shipped by Linux distributions and embedded in\nservices that may parse untrusted input. Triggering this vulnerability\nrequires the victim to open a malicious MOPAC output file with the\n`obabel` tool, the `OBConversion` API, or any of the language\nbindings (Python, Ruby, Java, R, Perl, C#, PHP).\n\n### Affected versions\n\nAll releases up to and including 3.1.1.\n\n### Patched version\n\n3.2.0 (released 2026-05-26).\n\n### Patch\n\nFix commit: https://github.com/openbabel/openbabel/commit/40e85213\n\nA minimized reproducer for this CVE is checked in under\n`test/files/fuzz_regress/` and is exercised on every CI build under\nASAN+UBSAN by the `fuzzregresstest` harness.\n\n### Credit\n\nReported by Cisco TALOS.",
  "severity" : [ {
    "type" : "CVSS_V3",
    "score" : "CVSS:3.1/AV:L/AC:L/PR:N/UI:R/S:U/C:H/I:H/A:H"
  } ],
  "affected" : [ {
    "package" : {
      "ecosystem" : "PyPI",
      "name" : "openbabel"
    },
    "ranges" : [ {
      "type" : "ECOSYSTEM",
      "events" : [ {
        "introduced" : "0"
      }, {
        "fixed" : "3.2.0"
      } ]
    } ]
  } ],
  "references" : [ {
    "type" : "WEB",
    "url" : "https://github.com/openbabel/openbabel/security/advisories/GHSA-55f6-pf8r-c2f4"
  }, {
    "type" : "ADVISORY",
    "url" : "https://nvd.nist.gov/vuln/detail/CVE-2022-46292"
  }, {
    "type" : "WEB",
    "url" : "https://github.com/openbabel/openbabel/commit/40e852138f21d586b7ccdce6329e7b23a87168bb"
  }, {
    "type" : "PACKAGE",
    "url" : "https://github.com/openbabel/openbabel"
  }, {
    "type" : "WEB",
    "url" : "https://talosintelligence.com/vulnerability_reports/TALOS-2022-1666"
  }, {
    "type" : "WEB",
    "url" : "https://www.talosintelligence.com/vulnerability_reports/TALOS-2022-1666"
  } ],
  "database_specific" : {
    "cwe_ids" : [ "CWE-119", "CWE-787" ],
    "severity" : "HIGH",
    "github_reviewed" : true,
    "github_reviewed_at" : "2026-07-06T16:41:43Z",
    "nvd_published_at" : null
  }
}